| 1939 | Company established with the name “Yamamaru Seiyaku.” |
|---|---|
| 1944 | Company established with the name “Yamamaru Seiyaku.” |
| 1950 | Succeeded in extracting and separating cystine from natural proteins. |
| 1953 | Began mass production of Cystine. L-Cystine used as additive in dry milk for infants. |
| 1962 | Began construction of main plant in Ashikaga City, Tochigi Prefecture. |
| 1971 | Ministry of Health and Welfare approved L-Cysteine as an additive for perm solutions. |
| 1983 | Obtained manufacturing patents for DL-Cysteine and Cystine. |
| 1985 | Received the Clean Japan Center’s Chairman’s Award for contributing to the reuse of resources. Succeeded at optically resolving synthetic cystine. |
| 1987 | Underwent first GMP inspection of US FDA. |
| 1999 | Completed new head office building. |
| 2004 | Obtained ISO 14001 certification. |
| 2005 | Underwent first GMP inspection of German regional authorities. |
| 2009 | Underwent second GMP inspection of German regional authorities. |
| 2011 | Underwent first GMP inspection of Korean FDA. |
| 2018 | Underwent eighth GMP inspection of US FDA. |
